THE RIPA-56 DIARIES

Mechanism of Action: Obeticholic acid is surely an agonist for Farnesoid X Receptor (FXR), a nuclear receptor expressed in the liver and intestine. FXR is usually a critical regulator of bile acid, inflammatory, fibrotic and metabolic pathways. FXR activation decreases the intracellular hepatocyte concentrations of bile acids by suppressing de nov

Oxidoreductase activity, performing on paired donors, with incorporation or reduction of molecular oxygen, decreased flavin or flavoprotein as just one donor, and incorporation of 1 atom of oxygenlevoketoconazole will enhance the amount or outcome of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.bortezomib